Chromosomal translocations often ARE what you're looking for when you do FISH testing (I am assuming you actually mean Fluorescence In Situ Hybridization testing and not FSH, which would mean follicle-stimulating hormone to an MD).
So I'm not sure what you mean by a false positive. FISH testing is used to look for chromosomal abnormalities. How it's used depends on what you're looking for. The basic technique is to use a fluorescent protein ';probe'; that is designed to stick to the particular DNA you're investigating. Then you look to see if there is anything lighting up (if you're looking for a chromosomal abnormality), or if there is more than the usual number of things lighting up (if you were looking for a triploidy--triplication of chromosomes--like in Down syndrome), or whatever. If whatever sequence you're investigating for isn't there, it won't light up.
Can you be more specific about what you mean by a false positive?
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